CLDN18.2 resources and expert videos

Download additional resources to learn more about how to consistently test, interpret, and report CLDN18.2 in G/GEJ cancer.

CLDN18.2 resources and expert videos
CLDN18.2 resources and expert videos

Resources

Publications and assessments

Fassan 2024 publication

Download the publication, “Claudin-18.2 Immunohistochemical Evaluation in Gastric and Gastroesophageal Junction Adenocarcinomas to Direct Targeted Therapy: A Practical Approach.”

Shitara 2024 publication

Download the publication, “Global Prevalence of Claudin 18 Isoform 2 in Tumors of Patients With Locally Advanced Unresectable or Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma.”

VENTANA® CLDN18 (43-14A) RxDx Assay
performance publication 2025

Download the publication, “Analytical and Clinical Performance of the VENTANA® CLDN18 (43-14A) RxDx Assay in Gastric and Gastroesophageal Junction Adenocarcinoma Tissue Samples in SPOTLIGHT and GLOW.”

Global concordance study publication

Download the global concordance study publication, which assesses the performance and reproducability of three CLDN18.2 antibodies: 43-14A, EPR19202, and ZR451 in gastric cancer.


2024 Quality in pathology (QuIP) independent proficiency testing study

Access the latest publication and more information about QuIP.

NordiQC External Quality Assessment

Access the 2025 assessment and more information about NordiQC.


Tools and guides

CADQAS CIC (Cancer Diagnostic Quality Assurance Services Community Interest Company)

CADQAS CIC is an independent, not-for-profit community interest company that supports the introduction and adoption of high-quality new cancer diagnostic and predictive biomarker tests

  • Purpose: Use quality assurance to ensure that the right patients are identified correctly for a given cancer treatment
  • Mission:
    • To undertake research and development to evaluate and ensure the quality and accuracy of new reagents, equipment, and tissue used in cancer diagnostic tests before they are used clinically to identify groups of patients suitable for targeted drug therapy
    • To support and train laboratories worldwide in the adoption, performance, administration, and accurate interpretation of new tests to ensure that the uptake of new cancer diagnostic technology is of the highest quality and to support knowledge transfer on quality assurance matters
  • Digital Interpretive Proficiency Testing (DIPT): CADQAS provides expertise, services, and infrastructure to support regional testing for selected IHC markers in tissue-based pathology worldwide—an initiative supported by the sponsorship of Astellas

CLDN18.2 reporting template

Download the guidance from our expert committee.

IHC assay guide

Explore our expert-recommended IHC Implementation Guide to help you set up a new biomarker assay in your lab.

eLearning center

Access a self-guided CLDN18.2 educational program.

IHC assay guide

Explore our expert-recommended IHC Implementation Guide to help you set up a new biomarker assay in your lab.

CLDN18.2=claudin 18 isoform. EQA=external quality assessment. G/GEJ=gastric/gastroesophageal junction. IHC=immunohistochemistry.

Peer perspectives

Hear from some of the world’s leading pathologists discussing how they test, interpret, and report CLDN18.2 expression.

What Is CLDN18.2?

Matteo Fassan, MD, PhD

How to Prepare Samples for CLDN18.2 Testing

Takeshi Kuwata, MD, PhD

How to Test for CLDN18.2

Christoph Röcken, MD

How to Interpret CLDN18.2

Josef H. Rüschoff,  MD

How to Report CLDN18.2

Kristina A. Matkowskyj, MD, PhD

CLDN18.2 expert committee

Matteo Fassan, MD, PhD

Matteo Fassan, MD, PhD

Trevigiana, Italy

Takeshi Kuwata, MD, PhD

Takeshi Kuwata, MD, PhD

Tokyo, Japan

Kristina A. Matkowskyj, MD, PhD

Kristina A. Matkowskyj, MD, PhD

Rochester, MN, USA

Christoph Röcken, MD

Christoph Röcken, MD

Kiel, Germany

Josef H. Rüschoff,  MD

Josef H. Rüschoff,  MD

Kassel, Germany

Kristina A. Matkowskyj, MD, PhD

Rochester, MN, USA

The experts above have been contracted as paid advisors through Astellas Pharma Inc. and have received compensation for their time. The content on this website has been created by Astellas Pharma Inc. and may or may not reflect the views of the experts shown above unless explicitly specified.